K9 Advantix II Main Uses
Monthly topical for dogs to kill and repel fleas, ticks, mosquitoes, and lice; also reduces biting from stable flies, helping prevent parasite-borne irritation and disease transmission in dogs.
Controls fleas (including all life stages: adult fleas, flea eggs, and flea larvae) on dogs.
Works through contact with parasites, meaning fleas and ticks do not need to bite the dog to be affected by the active ingredients.
Remains effective even after swimming and bathing.
 
K9 Advantix II Active Ingredients
Imidacloprid: Adulticidal neonicotinoid targeting fleas on contact; contributes to rapid flea kill on the dog’s skin and coat surface.
Permethrin: Pyrethroid that kills and repels ticks and mosquitoes; provides repellency that reduces bites from ticks, mosquitoes, and stable flies.
Pyriproxyfen: Insect growth regulator that disrupts development of flea eggs and larvae to break the flea life cycle.
 
K9 Advantix II Instructions
Age: Safe for dogs and puppies 8 weeks and older.
Weight-based: Available in size-specific tubes
small <4.5 kg
medium 4.6–11 kg
large 11–25 kg
extra-large >25 kg
Frequency: Apply once every 4 weeks year-round for continuous protection.
Application: Dog should be dry and standing; part hair and apply entire tube to skin. For dogs ≤25 kg, apply to one spot between shoulder blades; for dogs >25 kg, divide evenly across 5 spots from shoulders to base of tail. Do not rub in; allow to dry and prevent pets from grooming each other until dry.
Keep hair dry for about 24 hours after application.
 
K9 Advantix II Side Effects & Safety
For dogs only. DO NOT USE K9 ADVANTIX II ON CATS, KITTENS, OR ANY OTHER ANIMAL.
Permethrin is toxic to cats; cats should not be allowed around dogs treated with K9 Advantix II within the first 48 hours of application.
Common local reactions: Transient skin irritation at the application site (redness, itchiness, hair clumping) can occur; avoid applying to broken skin and prevent ingestion by licking before it dries.
Warnings/contraindications: For external use on dogs only; avoid eye contact and ingestion; follow disposal and handling instructions on the package.
Duration of use: Designed for monthly, ongoing use during flea and tick seasons or year-round as advised.
Consult a veterinarian before use in senior dogs, breeding, pregnant or lactating dogs, or dogs with dermatologic conditions.
 
K9 Advantix II Manufacturer Information
Manufacturer: Elanco
Official Website: https://mypetandi.elanco.com/en_ca/our-products/advantix
Brand Introduction: K9 Advantix II is manufactured by Elanco, a veterinary medicine company. The product is veterinarian recommended and widely distributed across Canada through major pet retailers. The Advantix line is part of Elanco's broader portfolio of parasitic control products designed to protect pets from fleas, ticks, mosquitoes, and other external parasites.