Advantage II Main Uses
Flea Prevention and Treatment: Indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) on dogs and puppies.
Life Cycle Control: Effectively breaks the flea life cycle by killing adult fleas, flea eggs, and flea larvae.
Lice Treatment: Treatment of lice infestations on dogs.
Flea Allergy Dermatitis (FAD): Used as part of a treatment strategy to manage FAD by rapidly reducing flea bites.
 
Advantage II Active Ingredients
Imidacloprid (9.1%): An adulticide that targets the flea's central nervous system. It causes overstimulation of the nerves, leading to paralysis and death of the adult flea upon contact.
Pyriproxyfen (0.46%): An Insect Growth Regulator (IGR) that mimics juvenile growth hormones. It prevents flea eggs from hatching and keeps larvae from molting into pupae or adults.
Mechanism of Action: This is a "contact" treatment. The active ingredients spread across the pet’s skin through the lipid (oil) layer. Parasites are killed when they touch the treated hair or skin; they do not need to bite the dog to be affected.
 
Advantage II Dosage & Administration
Recommended Dosage by Weight:
Advantage II Green for Small Dogs (under 4.5 kg): 0.4 mL per tube.
Advantage II Aqua for Medium Dogs (4.6–11 kg): 1.0 mL per tube.
Advantage II Red for Large Dogs (11–25 kg): 2.5 mL per tube.
Advantage II Blue for Extra Large Dogs (over 25 kg): 4.0 mL per tube.
Administration: Apply topically to the skin. For dogs less than 25 kg, apply to one spot between the shoulder blades. For dogs over 25 kg, apply evenly to 5 spots along the back from the shoulder to the base of the tail.
Frequency: Applied once every 4 weeks.
Timing: Ensure the dog is dry before application. Do not bathe, shampoo, or allow the dog to swim immediately after application. The pet may be bathed, exposed to rain, or immersed in water after 3 days following treatment.
 
Advantage II Side Effects & Safety
Common Side Effects: Minor skin irritation at the site of application (redness, itching, or hair loss).
Rare Side Effects: Gastrointestinal upset (vomiting, diarrhea), changes in behavior (lethargy, agitation), or excessive drooling if the product is accidentally ingested.
Contraindications:
Age/Weight: Do not use on puppies under 7 weeks of age or dogs below the minimum weight for the specific tube size.
Species: Do not use on cats.
Safety Warnings: Consult a veterinarian before use on sick, aged, pregnant, or nursing animals. Humans should wear gloves during application and wash hands thoroughly afterward.
 
Advantage II Manufacturer Information
Manufacturer: Elanco Canada (formerly a Bayer Animal Health product).
Official Website: https://www.elanco.com/en-ca
Brand Introduction: Elanco is a global leader in animal health, providing a wide range of pharmaceutical products and vaccines for pets and livestock. Advantage II is one of their flagship over-the-counter parasite preventatives, widely recognized for its "contact-kill" technology that differentiates it from oral medications.