Apoquel Main Uses:
Apoquel are mainly used to treat itching (pruritus) caused by allergic dermatitis and atopic dermatitis in dogs aged 12 months and older.
Apoquel provides fast and effective relief for allergy-related skin inflammation, with results typically seen within 4 to 48 hours of administration.
Apoquel works comparably to steroid medications, but it has fewer and milder side effects than traditional steroids.
Clinical studies indicate 60% of moderate to severe atopic dermatitis cases are controllable on once-daily dosing.
 
Apoquel Active ingredient:
Oclacitinib maleate: a Janus Kinase (JAK) inhibitor, primarily targeting JAK-1 and JAK-3 signaling pathways to block inflammatory cytokines that cause itch and inflammation (including IL-2, IL-4, IL-6, IL-13, and IL-31).
By blocking these cytokines, Apoquel interrupts the cycle of itching, scratching, and further skin damage, allowing the skin to heal.
 
Apoquel Dosage & Administration
Apoquel tablets come in 3 strengths to suit different dog weights:
3.6 mg
5.4 mg
16 mg 
Recommended dosage: 0.4–0.6 mg per kg of body weight, typically prescribed twice daily for the first 14 days, then once daily for maintenance.
Tablets can be given with or without food; some dogs may tolerate them better with food.
Dosage is strictly based on weight and age and veterinarians adjust dose for long-term use to minimize immune suppression.
Always use as directed by a veterinarian. Do not give extra doses if a dose is missed—resume as scheduled.
 
Apoquel Safety & Side Effects
Common side effects include: vomiting, diarrhea, decreased appetite, lethargy, skin or ear infections, and rarely, bone marrow suppression detected on bloodwork.
Stop the medication and contact your veterinarian immediately if you notice: Signs of a infection such as skin swelling, oozing, bleeding sores, frequent or painful urination, lack of energy, coughing, or poor appetite; New growths or an enlargement of existing skin masses.
Not recommended for dogs under 12 months due to risk of infections.
Apoquel is safe for long-term use in most dogs with regular veterinary monitoring.
 
Manufacturer Information
Manufacturer: Zoetis Canada Inc.
Official website: https://www2.zoetis.ca/
Brand introduction: Zoetis is a leading global animal health company specializing in innovative veterinary pharmaceuticals, vaccines, and diagnostic products for pets and livestock. Apoquel is among its flagship products for canine allergy management.
 
Download Apoquel Dosing Guide