Palladia Main Uses
Palladia (toceranib phosphate) is a prescription tiyrosine kinase inhibitor approved for treating grade II–III cutaneous mast cell tumors in dogs, including cases with or without regional lymph node involvement.
The medication has demonstrated therapeutic potential for treating various other cancers in dogs, including sarcomas, carcinomas (such as bladder cancer and mammary cancer), melanomas, anal sac adenocarcinoma, and multiple myeloma.
 
Palladia Active Ingredients
Toceranib phosphate: Inhibits receptor tyrosine kinases involved in tumor cell proliferation and survival and in tumor angiogenesis, helping slow division of cancer cells and reduce tumor blood vessel growth, which may shrink or stabilize tumors.
 
Palladia Dosage & Administration
It is in tablet form and is available in 10mg, 15 mg, 50 mg dosage strengths.
Administer PALLADIA orally at an initial dose of 3.25 mg/kg body weight every other day. If adverse reactions occur, the dose may be reduced by 0.5 mg/kg (not lower than 2.2 mg/kg every other day) or temporarily discontinued for up to two weeks, as needed. Always use as directed by a veterinarian.
Tablets should not be split or crushed unless directed by a veterinarian.
Perioperative timing: Avoid use for 3 days before surgery and for 2 weeks after surgery due to effects on wound healing and thrombotic risk.
May be given with or without food; if vomiting occurs fasting, give with food thereafter.
 
Palladia Side Effects & Safety
Common effects: diarrhea, decreased appetite (anorexia), vomiting, lethargy, weight loss, blood in stool/gastrointestinal bleeding, lameness, and musculoskeletal disorders.
Other potential effects: Hypertension, proteinuria, neutropenia, hepatopathy, lameness, pancreatitis, and cardiotoxicity.
Signs of liver or kidney problems may occur, including dark urine, increased thirst, changes in urination, and yellowing of the skin or eyes (jaundice).
Human safety: Use gloves for dosing and waste handling; prevent licking of skin for at least an hour post-dose; wash exposed areas thoroughly.
When to pause/stop: Veterinarians may recommend skipping doses or pausing therapy if significant side effects occur
Pregnant women should not handle this medication or any bodily waste from treated pets, and children should not come in contact with Palladia or broken/partially dissolved tablets.
 
Palladia Manufacturer Information
Manufacturer: Zoetis Services LLC.
Official Website: https://www2.zoetis.ca/
Brand Introduction: Zoetis is a veterinary pharmaceutical company that develops and manufactures medications for companion animals; Palladia is an FDA-approved prescription veterinary anti-cancer medication that has been approved by Health Canada for treating mast cell tumors in dogs
 
Reference:
https://www2.zoetis.ca/species/companion-animals/products-and-solutions/palladia-50-mg-30-tablets