PROIN Main Uses
Urinary Incontinence Control: Specifically indicated for the control of urinary incontinence due to urethral sphincter hypotonus (weakening of the muscles that hold the bladder closed) in dogs.
 
PROIN Active Ingredients
Phenylpropanolamine Hydrochloride (PPA): A sympathomimetic amine.
Mechanism of Action: It works by stimulating alpha-adrenergic receptors in the smooth muscle of the urethra. This increases the "tone" or tightness of the urethral sphincter, creating a stronger seal to prevent urine from leaking out of the bladder.
 
PROIN Dosage & Administration
Recommended Dosage: The standard total daily dose is 2 mg/kg of body weight twice daily.
Forms: Available in liver-flavored, scored chewable tablets (25 mg, 50 mg, and 75 mg) to allow for precise dosing in half-tablet increments.
Administration Timing: Can be given with or without food. If the dog experiences nighttime accidents, veterinarians may suggest giving a dose shortly before bedtime.
 
PROIN Side Effects & Safety
Common Side Effects: Vomiting, loss of appetite, increased thirst (polydipsia), restlessness, irritability, high blood pressure and a slight increase in heart rate.
Serious Side Effects: Rare but severe reactions include seizures, stroke-like symptoms, or collapse.
Contraindications & Warnings:
Do not use in dogs with pre-existing high blood pressure (hypertension).
Use with caution in dogs with heart disease, kidney insufficiency, liver disease, diabetes, or glaucoma.
Do not use in pregnant or lactating dogs.
Safe Duration: Often used as a lifelong management tool, but requires regular veterinary monitoring of blood pressure and heart health.
 
PROIN Manufacturer Information
Manufacturer: Virbac Canada
Official Website: https://ca.virbac.com
Brand Introduction: Virbac is a major global animal health company with a significant presence in Canada. PROIN is one of the most widely recognized prescription treatments for canine urinary issues, known for its palatable liver-flavored tablets that improve owner compliance.