Advantage II Main Uses
Monthly topical flea treatment and prevention for cats; kills adult fleas and controls flea eggs and larvae to break the flea life cycle; help manage flea allergy dermatitis (FAD) and skin infections caused by flea bites.
Acts on contact so fleas do not need to bite to die; useful in homes with active infestations to reduce environmental stages carried on the cat’s coat.
Killing adult fleas within 2 hours of application, with continuous protection for 28 days
 
Advantage II Active Ingredients
Imidacloprid (9.1%): Kills adult fleas through contact on the skin/coat oils without systemic absorption, leading to paralysis and death of fleas.
Pyriproxyfen (0.46%): Insect growth regulator that prevents development of eggs and larvae; shed fur/skin can distribute minute amounts in the environment to disrupt the life cycle in the home.
The product is not absorbed into the bloodstream but remains locked in the oils of the cat's skin and quickly spreads across the entire skin surface.
 
Advantage II Dosage & Administration
Age eligibility: for cats and kittens 8 weeks of age and older; select product by weight band.
Weight‑based products and typical monthly volumes:
Kittens 0.9–2.3 kg (2–5 lb) : Aqua (0.23 mL) monthly.
Small cats 2.3–4 kg (5–9 lb) : Orange (0.40 mL) monthly.
Large cats over >4 kg (>9lb): Purple (0.80 mL) monthly.
Administration: apply entire tube to skin at base of skull/neck where the cat cannot lick; part hair to reach skin; one tube every 30 days; avoid eyes and ingestion; discard empty applicator safely.
Avoid bathing for about 48 hours around application to preserve product in skin oils for spot‑ons.
Early re‑dosing guidance in heavy infestations: do not apply more than one tube per treatment; if necessary, minimum intervals advised are 14 days for kittens (2–5 lb) and 7 days for small/large cats until control is achieved, then return to monthly dosing.
 
Advantage II Side Effects & Safety
Generally well-tolerated with mild side effects that may include temporary skin irritation at the application site, brief periods of increased grooming behavior, mild drooling if the product is licked, and occasional lethargy or agitation
Use on cats and kittens 8 weeks of age and older weighing over 2 pounds
Do NOT administer by mouth or allow the cat to ingest the product
Avoid contact with the cat's eyes during application
Duration of use: labeled for monthly, year‑round use as needed for flea prevention and control; continue monthly in environments with ongoing risk to maintain protection.
 
Advantage II Manufacturer Information
Manufacturer: Elanco
Official Website: https://mypetandi.elanco.com/en_ca/our-products/advantage/advantage-ii-cats
Brand Introduction: Advantage II is manufactured by Elanco, a veterinary medicine company. The product is veterinarian recommended and widely distributed across Canada through major pet retailers. The Advantage line is part of Elanco's broader portfolio of parasitic control products designed to kill adult fleas and inhibit immature stages for household flea management in cats.